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Appendix Cancer: Uniting For Strength, Inspiring Hope Together

Appendix cancer poses significant challenges, often diagnosed late. Yet, through early detection, advanced treatments, and unwavering support, we strive to improve outcomes and offer hope to those affected.

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Insights Of Appendix Cancer

With extensive training, experience, and dedication to patient care offering the comprehensive services tailored to meet the unique needs of each individual.

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Appendix Overview: Essential Functions

The appendix is a small, hollow tube that connects the large colon (also known as the large intestine or large bowel).The appendix may develop cancer very rarely. Appendix cancer is frequently categorized as a form of colorectal cancer due to its connection to the colon.

Your Appendix Has Two Major Parts :
  • The appendix has a worm-shaped shape and measures about 4 inches in length. Although it is possible that the appendix contributes to the immune system, its function is unknown.
  • The prognosis (outlook) is directly correlated with tumor size. Tumors of the appendix that are less than two centimeters in size are less likely to spread, but tumors that are more than 2.5 centimeters in size may require more aggressive treatment
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Types Of Appendix Tumors

Tumor types of the appendix Like many other organs in the body, the appendix contains cells that make hormones. A carcinoid tumor is one that arises from cells that make hormones. Non-carcinoid tumors do not originate from hormone-producing cells.

Which Part Of The Pancreas Is Affected With Cancer:
  • Pancreatic cancer can manifest in various parts of the pancreas, with a higher incidence observed in the head of the pancreas, particularly near the ampulla.
  • The term “periampullary disease” is often used to denote the location of the cancer, which can be situated in the head of the pancreas, at the ampulla, at the lower end of the bile duct, or at the point where the pancreatic duct joins the intestine.
Carcinoid Tumor:

A carcinoid tumor begins in the hormone-producing cells, which are typically found in small quantities in nearly every body organ. A carcinoid tumor typically develops in the lungs or gastrointestinal tract, but it can also develop in a person's pancreas, testicles, or ovaries.

  • Carcinoid tumors constitute around 66% of all appendix tumors, often remaining asymptomatic until discovered incidentally during unrelated medical procedures.
  • Surgery offers favorable outcomes for treating localized appendix carcinoid tumors, with a high success rate when the tumor remains confined to its original site.
Non-Carcinoid Tumors:

The epithelial cells that line the inside of the appendix are the source of non-carcinoid tumors of the appendix. The majority of these tumor-forming cells produce mucin, a gelatinous substance.

  • Non-carcinoid appendix tumors pose a risk of perforation, leading to the dissemination of tumor cells and mucin throughout the abdominal cavity.
  • Accumulation of tumor cells and mucin over time in untreated cases can result in pseudomyxoma peritonei, characterized by cachexia and potentially fatal bowel obstruction.
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The Causes Of Appendix Cancer

Reference section malignant growth has no known reason. There are currently no known ways to alter one’s lifestyle to lower one’s risk of developing appendix cancer.

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Explore Some Common Symptoms Of The Appendix Cancer

Appendix cancer does not present with symptoms until it has advanced. Appendicitis or appendix rupture may result from appendix cancer. Once in a while this is the primary side effect of reference section malignant growth.

Peritonitis, a serious infection of the lining of the abdomen and pelvis, can result from a ruptured appendix. Additionally, cancerous appendix tumors can “seed” the abdomen with cancer cells. This could lead to the development of additional cancerous tumors in the abdomen before it is discovered.

One of the underlying causes of such bleeding may be colorectal cancer. If the test comes back positive, your doctor will provide you with additional information.

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Treatment For Appendix Cancer

The type of tumor, its location within the appendix, and whether or not it has spread all play a role in how appendix cancer is treated.

  • Limited evaluation of treatment options in standard clinical trials due to low incidence rates, especially for non-carcinoid tumors.
  • Common procedures include appendectomy or right colon removal for affected patients.

The Tests Carried Out To Diagnose Appendix Cancer

The majority of the time, appendix cancer goes undiagnosed until it is discovered unexpectedly during or after abdominal surgery or when an abdominal mass is detected on a CT scan for a condition that is unrelated.

During abdominal surgery, if appendix cancer is suspected, the surgeon would collect a tissue sample (biopsy) for a pathologist to examine. Otherwise, as part of the routine pathology reading following your abdominal surgery, the cancer may be identified. If that is the case, additional surgery may be suggested to ensure that all cancerous tissue has been removed.

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Surgery For Appendix Cancer

Appendix Cancer Surgery The majority of carcinoid tumors are small (less than two centimeters) and very unlikely to spread to nearby lymph nodes. In these instances, appendectomy, or the removal of the appendix, is sufficient treatment. The likelihood of a tumor spreading to the liver and surrounding lymph nodes is slightly higher in larger tumors.

The right colon and regional lymph nodes should be removed. Right Hemicolectomy) It appears that a combination of cytoreductive (tumor debulking) surgery and hyperthermic intraperitoneal (i.e., in the abdominal cavity) chemotherapy is the most effective treatment for patients with non-carcinoid tumors that have spread within the abdominal cavity

For gallbladder cancer, there are two general types of surgical treatment: potentially curative surgery and palliative surgery.

Explore The Different Required Stages Of Surgery

Cytoreduction (Debulking) Surgery:

By the time an appendix cancer is discovered, it frequently has spread to the abdomen's peritoneal surfaces. The completeness of cytoreduction, or the removal of all tumors that are visible, is the factor that is most closely linked to long-term survival.

  • “Debulking” or “cytoreduction” surgery is the procedure of removing as much of the cancer in the abdomen as possible and reducing the “bulk” of the cancer. Since “cyto” is derived from the root word “cells,” “cytoreduction” refers to the surgical “reduction” of cancer cells. The two terms are frequently used interchangeably and mean the same thing.
  • Cytoreduction (debulking) surgery often takes a long time, is complicated, and is big to get rid of all the tumor and mucus in the abdominal cavity.
  • Parts of the intestine, the gallbladder, the spleen, the ovaries, the uterus, and even the lining of the abdominal cavity (peritoneum) may need to be removed as a result. The term “complete cytoreduction” or “complete debulking” refers to the successful surgical removal of all observable tumors.
  • The term “incomplete cytoreduction” or “incomplete debulking” refers to the fact that the surgery was unable to remove all of the tumors, leaving only the ones that were visible.
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Hyperthermic Intraperitoneal Chemotherapy (HIPEC):

The surgery can be followed by treatment with intraoperative Hyperthermic Intraperitoneal Chemotherapy or treatment with early post-operative intraperitoneal chemotherapy (EPIC) at facilities that are capable of providing these treatments to destroy very small tumors and cancer cells that are left behind that are too small to be seen and to prevent them from later growing into new cancerous tumors in the abdomen. Both of these treatments can be used to treat tumors that are too small to be seen.

  • These chemotherapy treatments might be able to kill very small tumors that can’t be removed, but they can’t kill all of the larger tumors that are left behind.
  • If the tumor is completely debulked, HIPEC is only done. A chemotherapy drug is injected into the abdominal cavity during surgery and heated to over 40 degrees Celsius. The abdomen of the patient is then gently rocked back and forth for 90 minutes to ensure that the chemotherapy kills all tumor cells in the abdominal cavity.

Chemotherapy:

Appendix cancer is usually treated with the same drugs that are used to treat colon cancer when intravenous chemotherapy (IV chemo) is prescribed.

  • Clinical trials comparing the efficacy of various available chemotherapy agents have not been conducted because appendix cancer is so uncommon.
  • The effectiveness of these chemotherapy medications is assumed to be beneficial in the treatment of appendix cancer because the pathologies of colon cancer and appendix cancer are similar. In many instances, it has been demonstrated to be effective. Most frequently a mix of a few medications is utilized.
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Symptoms may include abdominal pain that starts near the navel and shifts to the lower right abdomen, abdominal swelling or bloating, changes in bowel habits, and unexplained weight loss.

Diagnosis typically involves imaging tests such as CT scan or MRI, blood tests including tumor markers like CEA (carcinoembryonic antigen), and confirmation through surgical biopsy or removal of the appendix (appendectomy).

Appendix cancer risk factors include age (more common over 50), gender, genetic syndromes like FAP or HNPCC, chronic inflammation, smoking, and family history, although it's rare.

Treatment depends on the type and stage of the cancer but may include surgery to remove the appendix and surrounding tissue, chemotherapy, and sometimes, additional treatments like radiation therapy or targeted therapy. Clinical trials may also offer new treatment options.

The exact cause of appendix cancer is unknown, so prevention strategies focus on maintaining overall health, avoiding smoking, and promptly addressing any abdominal symptoms. Regular medical check-ups are essential for early detection and timely treatment.

Looking For Another Perspective On Appendix Cancer Insights?

About doctor

Dr. Deepak Chhabra

MS. (Bom), DNB, M.R.C.S. (Edin. UK)
Fellow GI Surgical Oncology & Robotics (Seoul, Korea)
Specialist HPB Training (Nagoya Univ, Japan)

Dr. Deepak Chhabra is a consultant Surgical Oncologist with an extensive experience in cancer surgeries. He is has specialized in Hepato (Liver) -Biliary (Gallbladder) and Pancreatic Cancer Surgeries.

  • Member at the Department of Surgical Oncology at Lilavati Hospital, Mumbai
  • First clinical Co-Ordinator of the Asia-Pacific Neuroendocrine tumor registry (AP-NET registry) in India.
  • One of few specialist in Hepatobiliary and Pancreatic Cancer Surgeries from Nagoya University in Japan.
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15

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5000

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  • He is one of the prestigious Appendix Cancer Doctor in Mumbai.
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    “Two years back had my father's major Liver surgery done by Doctor Deepak Chhabra, right now he is absolutely fit and fine. As a Doctor he is very well mannered calm & easily understand the condition of the patient. He use to explain comprehensively about the infection and procedure of surgery and its pros and cons. Respectful Doctor in the field of Oncosurgery/Surgical Oncology in mumbai. Recommended doctor by some of the best Cancer Doctors & Medical Oncologist in Mumbai."

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